Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized rats
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منابع مشابه
Mixed tocopherols inhibit N-methyl-N-nitrosourea-induced mammary tumor growth in rats.
Tocopherols are present in significant amounts in vegetable oils used in human foods. The most prevalent tocopherols in foods are the alpha, beta, gamma, and delta variants with (RRR) stereochemistry. Tocopherols are lipophilic phenolic antioxidants, produced by plants. In the United States, gamma-tocopherol is the most prominent dietary tocopherol due to its high amount in the dominant commerc...
متن کاملInduction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor.
The importance of epidermal growth factor (EGF) in both normal and malignant mammary gland development are presented in these studies. Initial findings demonstrated that in the absence of ovarian hormones, EGF had a significant proliferative effect on mammary epithelial cells. To determine whether mammary epithelial cells grown with EGF, in the absence of ovarian hormones, could be transformed ...
متن کاملMetabolism of retinol and retinoic acid in N-methyl-N-nitrosourea-induced mammary carcinomas in rats.
This study was conducted to examine the in vivo uptake and metabolism of natural retinoids by N-methyl-N-nitrosourea-induced mammary carcinomas. In this study, endogenous retinol and retinyl esters were present in normal mammary epithelial cells, but were undetectable in N-methyl-N-nitrosourea-induced mammary carcinomas in rats as determined by high-pressure liquid chromatography. No difference...
متن کاملN -Methyl- N -nitrosourea-induced Renal Tumors in Rats: Immunohistochemical Comparison to Human Wilms Tumors
N-Methyl-N-nitrosourea (MNU)-induced renal tumors in rats and Wilms tumors in humans were compared. Renal mesenchymal tumors (RMTs) and nephroblastomas (blastemal and epithelial components) in female Lewis rats treated with a single intraperitoneal injection of 50 mg/kg MNU at birth and Wilms tumors (blastemal, epithelial and mesenchymal components) in humans were analyzed for the expression of...
متن کاملInhibition of growth of established N-methyl-N-nitrosourea-induced mammary cancer in rats by retinoic acid and ovariectomy.
Retinoids are effective in the prevention of N-methyl-N-nitrosourea-induced mammary carcinoma; retinoids and hormonal therapy exert synergy in cancer prevention. In this study, we examined the effects of the dietary supplementation with all-trans retinoic acid (RA) alone or in combination with ovariectomy on the growth of established N-methyl-N- nitrosourea-induced mammary carcinomas in rats. I...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2001
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/22.12.2039